This guidance document published in 2011 by PEPFAR is a response to the urgent need to strengthen and expand HIV prevention for MSM and their partners and to improve MSM’s ability to access HIV care and treatment. It furthers PEPFAR’s renewed emphasis on matching interventions and investments with epidemiological trends and needs in order to improve impact. This guidance also builds upon and strengthens international efforts to encourage comprehensive HIV prevention programs for MSM in low- and middle-income countries.